Directed by:
- Nora Ephron
Writing credits:
- Nora Ephron
- Delia Ephron
- Sol Saks
Cast:
- Nicole Kidman ... Isabel Bigelow / Samantha
- Will Ferrell ... Jack Wyatt / Darrin
- Shirley MacLaine ... Iris Smythson / Endora
- Michael Caine ... Nigel Bigelow
- Jason Schwartzman ... Ritchie
- Kristin Chenoweth ... Maria Kelly
- Heather Burns ... Nina
- Jim Turner ... Larry
- Stephen Colbert ... Stu Robison
- David Alan Grier ... Jim Fields
- Michael Badalucco ... Joey Props
- Carole Shelley ... Aunt Clara
- Steve Carell ... Uncle Arthur
- Katie Finneran ... Sheila Wyatt
- James Lipton ... Himself
- Conan O'Brien ... Himself
- Amy Sedaris ... Gladys Kravitz
- Richard Kind ... Abner Kravitz
- Ken Hudson Campbell ... Writer (as Ken Campbell)
- P.J. Byrne ... Writer
- Carole Androsky ... Realtor (as Carol Androsky)
- Annie Mumolo ... Bed, Bath and Beyond Shopper
- Andrew Friedman ... Bed, Bath and Beyond Shopper
- Clay Bravo ... Coffee Shop Waitress
- Heather Freedman ... Beverly Hills Hotel Hostess
- Jonathan T. Floyd ... Cable Man (as Jonathan Floyd)
- Ed McMahon ... Himself
- Alison MacInnis ... Auditioning Actress
- Bridget Brno ... Auditioning Actress
- Dana Daurey ... Auditioning Actress
- Dorie Barton ... Auditioning Actress
- Katie Carroll ... Auditioning Actress (as Katharine Carroll)
- Jennifer Elise Cox ... Auditioning Actress
- Laura Sorenson ... Auditioning Actress
- Brittany Paige ... Auditioning Actress
- Dawn Ashley Cook ... Auditioning Actress
- Julia Schuler ... Auditioning Actress
- Abbey McBride ... Auditioning Actress
- Jennifer Hall ... Book Soup Cafe Waitress
- Roxanne Beckford ... Francine
- Hugh Davidson ... Network Executive
- Joe Zymblosky ... Randall
- J.J. Sacha ... Voice-Over Announcer
- Susan Chuang ... Press Conference Reporter
- Jordan Black ... Press Conference Photographer
- Mo Rocca ... E! Reporter
- Jason Winston George ... E! Anchor (as Jason George)
- Wendi McLendon-Covey ... E! Anchor
- Julie Claire ... Hillary
- Terry Savage ... Dinner Party Guest
- Dianne Dreyer ... Production Staff Assistant
- Kate Walsh ... Sexy Waitress
- Valerie Azlynn ... Gorgeous Model
- Jarrad Paul ... Valet
- Victor Williams ... Police Officer
- Liesel Staubitz ... Trick-or-Treater
- Ruby Rose Skotchdopole ... Trick-or-Treater
- Molly Gordon ... Trick-or-Treater
- Nick Lachey ... Vietnam Soldier
- Sunday Boling ... Press Reporter
- Colleen Dunn ... Dance Double
- Meredith Giangrande
- Evan Grayson ... Valet
- Jennifer Haworth ... Dinner Party Guest
- Paul Lynde ... Uncle Arthur
- Jessica Mathews ... Samantha lookalike
- Chrissy May ... Samantha Auditioner
- Katie Melcer ... Television Executive
- Elizabeth Montgomery Samantha Stephens
- Agnes Moorehead ... Endora
- Maria Nicotero ... Auditioning Actress
- Robert O'Connor ... Party Guest 2
- Mina Olivera ... Dinner Guest
- Dan Ostermann ... Dixieland Bandmember
- Sean Scarborough ... Janitor
- Jennifer Shumaker ... Halloween Mom
- Scott Alan Smith ... Dinner Party Guest
- Larry Sullivan ... Dinner Party Guest
- Sheila Thomas ... Press Conference Reporter
- Danielle Weeks ... Auditioning Actress
- Dick York ... Darrin Stephens
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