Directed by:
- Bobby Farrelly
- Peter Farrelly
Written by:
- Marc Hyman
Main cast:
- Bill Murray ... Frank Detorre
- Molly Shannon ... Mrs. Boyd
- Chris Elliott ... Bob
- Elena Franklin ... Shane Detorre
- Danny Murphy ... Zookeeper Superintendent
- Jack McCullough ... Zookeeper
- Kathy Wege ... Mrs. Claris, Volcano Lady
- Will Dunn ... Oyster Boy
- Chris Rock ... Osmosis Jones (voice)
- Laurence Fishburne ... Thrax (voice)
- David Hyde Pierce ... Drix (voice)
- Brandy Norwood ... Leah (voice)
- William Shatner ... Mayor Phlegmming (voice)
- Ron Howard ... Tom Colonic (voice)
- Kid Rock ... Kidney Rock (voice)
.